Key TakeawaysCrypto-related stocks trade lower pre-market, led by Circle (CRCL) down 2.3%.MicroStrategy (MSTR) falls 1.66%, while Coinbase (COIN) drops 1.88%.Bitcoin miners and related equities also decline, reflecting weaker risk sentiment.Broader move signals cautious positioning ahead of market open.Crypto-related stocks in the U.S. are trading broadly lower in pre-market hours, tracking cautious sentiment across digital asset markets.Circle (CRCL) declined 2.3%, leading losses among crypto-linked equities. Other notable movers include ALTS (-1.48%), UPXI (-3.36%), BMNR (-2.45%), and SBET (-2.34%).Major crypto proxies also edged lower. Shares of MicroStrategy fell 1.66%, while Coinbase dropped 1.88%. Bitcoin mining stocks also weakened, with MARA down 2.17%.The declines come amid subdued momentum in Bitcoin and broader risk assets, as macro uncertainty and geopolitical developments continue to weigh on sentiment.Data cited from msx.com, a decentralized real-world asset (RWA) trading platform offering tokenized exposure to U.S. equities and ETFs, indicates the pullback is widespread across crypto-linked names.The pre-market weakness suggests investors remain cautious ahead of the U.S. trading session, with crypto equities continuing to act as a high-beta proxy for Bitcoin price movements and overall market risk appetite.