Santiment said in a post on X that the average trading return is a good indicator of whether it is really the right time to "buy low" or "sell high". Currently, active wallets in the past 30 days are in negative range for BTC, ETH, ADA and DOGE, as well as the vast majority of altcoins.
When MVRV is negative, it means buying or increasing holdings while others are already losing money. Historically, these "blood in the streets" moments are when professional traders make money.
Trade carefully and don't think these opportunity zone signals will lead to an immediate improvement. But the odds suggest that cryptocurrencies will improve in the short to medium term, at least, provided that economic or geopolitical factors do not hinder momentum.